Nigel Belshaw
Project Leader
Research Area: Integrated Biology of GI Tract
Contact Details:
Institute of Food Research,
Norwich Research Park,
Colney, Norwich,
NR4 7UA
UK
nigel.belshaw@bbsrc.ac.uk
Research interests
Understanding the mechanisms by which dietary factors, inflammation and the gut microflora drive aberrant CpG island methylation leading to neoplasia in the gastrointestinal tract.
Using CpG island methylation as predictive biomarkers for risk of neoplastic progression.
Recent Publications
Belshaw N. J., Pal N., Tapp H. S., Dainty J. R., Lewis M. P. N., Williams M. R., Lund E. K., Johnson I. T. (2010)
Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa
Carcinogenesis 31 (6) 1158-1163
Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa
Carcinogenesis 31 (6) 1158-1163
Johnson I. T., Belshaw N. J., Elliott G. O. (2009)
DNA methylation
Chemoprevention of Cancer and DNA Damage by Dietary Factors
WILEY-VCJ Verlag, Weinheim, Germany
1 (10) 153-162
DNA methylation
Chemoprevention of Cancer and DNA Damage by Dietary Factors
WILEY-VCJ Verlag, Weinheim, Germany
1 (10) 153-162
Belshaw N. J., Elliott G. O., Foxhall R. J., Dainty J. R., Pal N., Coupe A., Garg D., Bradburn D. M., Mathers J. C., Johnson I. T. (2008)
Profiling cpg island field-methylation in both morphologically normal and neoplastic human colonic mucosa
British Journal of Cancer 99 (1) 136-142
DOI:10.1038/sj.bjc.6604432
Profiling cpg island field-methylation in both morphologically normal and neoplastic human colonic mucosa
British Journal of Cancer 99 (1) 136-142
DOI:10.1038/sj.bjc.6604432
Johnson I. T. , Belshaw N. J. (2008)
Environment, diet and gpg island methylation: Epigenetic signals in gastrointestinal neoplasia
Food and Chemical Toxicology 46 1346-1359
Environment, diet and gpg island methylation: Epigenetic signals in gastrointestinal neoplasia
Food and Chemical Toxicology 46 1346-1359
Pierini R., Gee J. M., Belshaw N. J., Johnson I. T. (2008)
Flavonoids and intestinal cancer
British Journal of Nutrition 99 (E-Suppl. 1) ES53-ES59
Flavonoids and intestinal cancer
British Journal of Nutrition 99 (E-Suppl. 1) ES53-ES59
Pierini R., Kroon P. A., Guyot S., Ivory K., Johnson I. T., Belshaw N. J. (2008)
Procyanidin effects on oesophageal adenocarcinoma cells strongly depends on the flavan-3-ol degree of polymerisation.
Molecular Nutrition & Food Research 52 1399-1407
Procyanidin effects on oesophageal adenocarcinoma cells strongly depends on the flavan-3-ol degree of polymerisation.
Molecular Nutrition & Food Research 52 1399-1407
Pierini R., Kroon P. A., Guyot S., Johnson I. T., Belshaw N. J. (2008)
The procyandin-mediated induction of apoptosis and cell-cycle arrest in oesophageal adenocarcinoma cells is not dependent on p21cip1/waf1
Cancer Letters 270 (2) 234-241
DOI:doi:10.1016/j.canlet.2008.05.004
The procyandin-mediated induction of apoptosis and cell-cycle arrest in oesophageal adenocarcinoma cells is not dependent on p21cip1/waf1
Cancer Letters 270 (2) 234-241
DOI:doi:10.1016/j.canlet.2008.05.004
Fax: +44(0)1603 507723