Our Publications

2010

Bowden S D, Ramachandran V K, Knudsen G M, Hinton J C, Thompson A. An incomplete TCA cycle increases survival of Salmonella Typhimurium during infection of resting and activated murine macrophages. PLoS One. 2010, 5(11): e13871.

Layton A N, Hudson D L, Thompson A, Hinton J C, Stevens J M, Galyov E E, Stevens M P. Salicylidene acylhydrazide-mediated inhibition of type III secretion system-1 in Salmonella enterica serovar Typhimurium is associated with iron restriction and can be reversed by free iron. FEMS Microbiol Lett. 2010, 302(2): 114-22.

Alston M J, Seers J, Hinton J C, Lucchini S. BABAR: an R package to simplify the normalisation of common reference design microarray-based transcriptomic datasets.  BMC Bioinformatics. 2010, 11: 73.

2009

Bowden S D, Rowley G, Hinton J C, Thompson A. Glucose and glycolysis are required for the successful infection of macrophages and mice by Salmonella enterica serovar typhimurium. Infect Immun. 2009, 77: 3117-26.

Lucchini S, McDermott P, Thompson A, Hinton J C. The H-NS-like protein StpA represses the RpoS (sigma 38) regulon during exponential growth of Salmonella Typhimurium. Mol Microbiol. 2009, 74(5): 1169-86.

Wright J A, Tötemeyer S S, Hautefort I, Appia-Ayme C, Alston M, Danino V, Paterson G K, Mastroeni P, Ménager N, Rolfe M, Thompson A, Ugrinovic S, Sait L, Humphrey T, Northen H, Peters S E, Maskell D J, Hinton J C, Bryant C E. Multiple redundant stress resistance mechanisms are induced in Salmonella enterica serovar Typhimurium in response to alteration of the intracellular environment via TLR4 signalling. Microbiology. 2009, 155(Pt 9): 2919-29.

Hamilton S, Bongaerts R J, Mulholland F, Cochrane B, Porter J, Lucchini S, Lappin-Scott H M, Hinton J C. The transcriptional programme of Salmonella enterica serovar Typhimurium reveals a key role for tryptophan metabolism in biofilms. BMC Genomics. 2009, 10: 599.

Pin C, Rolfe M D, Muñoz-Cuevas M, Hinton J C, Peck M W, Walton N J, Baranyi J. Network analysis of the transcriptional pattern of young and old cells of Escherichia coli during lag phase. BMC Syst Biol. 2009, 3: 108.

Papenfort K, Said N, Welsink T, Lucchini S, Hinton J C, Vogel J. Specific and pleiotropic patterns of mRNA regulation by ArcZ, a conserved, Hfq-dependent small RNA. Mol Microbiol. 2009, Oct;74: 139-58.

Pfeiffer V, Papenfort K, Lucchini S, Hinton J C, Vogel J. Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation. Nat Struct Mol Biol. 2009, 16: 840-6.

Webber M A, Bailey A M, Blair J M, Morgan E, Stevens M P, Hinton J C, Ivens A, Wain J, Piddock L J. The global consequence of disruption of the AcrAB-TolC efflux pump in Salmonella enterica includes reduced expression of SPI-1 and other attributes required to infect the host. J Bacteriol. 2009, 191: 4276-85.

Arques J L, Hautefort I, Ivory K, Bertelli E, Regoli M, Clare S, Hinton J C, Nicoletti C. Salmonella induces flagellin- and MyD88-dependent migration of bacteria-capturing dendritic cells into the gut lumen. Gastroenterology. 2009 , 137(2): 579-87.

Prior K, Hautefort I, Hinton J C, Richardson D J, Rowley G. All stressed out. Salmonella pathogenesis and reactive nitrogen species. Adv Microb Physiol. 2009, 56:1-28.

2008

Sittka A, Lucchini, S, Papenfort K, Sharma CM, Rolle K, Binnewies TT, Hinton JC Vogel J. Deep sequencing analysis of small noncoding RNA and mRNA targets of the global post-transcriptional regulator, Hfq. PLoS Genet. 2008 Aug 22;4(8):e1000163. [ Abstract ] [ PDF ] [Supplementary data]

Clarke TA, Mills PC, Poock SR, Butt JN, Cheesman MR, Cole JA, Hinton JC, Hemmings AM, Kemp G, Söderberg CA, Spiro S, Van Wonderen J, Richardson DJ .Escherichia coli Cytochrome c Nitrite Reductase NrfA. Methods Enzymol. 2008;437:63-77 [ Abstract ] [ PDF ]

Papenfort K, Pfeiffer V, Lucchini S, Sonawane A, Hinton JC, Vogel J. Systematic deletion of Salmonella small RNA genes identifies CyaR, a conserved CRP-dependent riboregulator of OmpX synthesis.Mol Microbiol. 2008 Apr 8 [Epub ahead of print] [ Abstract ] [ PDF ]

Mills PC, Rowley G, Spiro S, Hinton JC, Richardson DJ. A combination of cytochrome c nitrite reductase (NrfA) and flavorubredoxin (NorV) protects Salmonella enterica serovar Typhimurium against killing by NO in anoxic environments.Microbiology. 2008 Apr;154(Pt 4):1218-28 [ Abstract ] [ PDF ]

McFarland KA, Lucchini S, Hinton JC, Dorman CJ. The leucine-responsive regulatory protein, Lrp, activates transcription of the fim operon in Salmonella enterica serovar Typhimurium via the fimZ regulatory gene. J Bacteriol. 2008 Jan;190(2):602-12 [ Abstract ] [ PDF ]

Hautefort I, Thompson A, Eriksson-Ygberg S, Parker ML, Lucchini S, Danino V, Bongaerts RJ, Ahmad N, Rhen M, Hinton JC. During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems. Cell Microbiol. 2008 Apr;10(4):958-84 [ Abstract ] [ PDF] [ Supplementary data S1 ][ Supplementary data S2 ][ Supplementary data S3][ Supplementary data S4] [ Supplementary data S5][ Supplementary data S6 ][ Supplementary data S7] [ Supplementary data S8 ][ Supplementary data S9 ] [ Supplementary data S10] [ Supplementary data S11] [ Supplementary data S12 ][ Supplementary data S13 ] [ Supplementary data S14 ][ Supplementary data S15 ][ Supplementary data S16 ][ Supplementary data S17 ]

2007

Ou HY, He X, Harrison EM, Kulasekara BR, Thani AB, Kadioglu A, Lory S, Hinton JC, Barer MR, Deng Z, Rajakumar K. MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands.Nucleic Acids Res. 2007 Jul 1;35(Web Server issue):W97-W104. Epub 2007 May 30 [ Abstract ] [ PDF ]

Rytkönen A, Poh J, Garmendia J, Boyle C, Thompson A, Liu M, Freemont P, Hinton JC, Holden DW. SseL, a Salmonella deubiquitinase required for macrophage killing and virulence.
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3502-7. Epub 2007 Feb 20. [ Abstract ] [ PDF ]

2006

Papenfort K., Pfeiffer V., Mika F., Lucchini S., Hinton J.C., Vogel J. sigma(E)-dependent small RNAs of Salmonella respond to membrane stress by accelerating global omp mRNA decay.
Mol Microbiol. 2006 Dec;62(6):1674-88 [ Abstract ] [ PDF(0.64 MB) ] [ Supplementary data S1 and S3 (3.8 Mb) ] [ Supplementary data S2(1 Mb) ] .

Balbontin R., Rowley G., Pucciarelli M.G., Lopez-Garrido J., Wormstone Y., Lucchini S., Garcia-Del Portillo F., Hinton J.C., Casadesus J. DNA adenine methylation regulates virulence gene expression in Salmonella enterica serovar Typhimurium.
J Bacteriol. 2006 Dec;188(23):8160-8. Epub 2006 Sep 22 [ Abstract ] [ PDF(0.22 MB) ] [ Supplementary data (2 Mb) ]

Nagy G., Danino V., Dobrindt U., Pallen M., Chaudhuri R., Emody L., Hinton J.C., Hacker J. Down-regulation of key virulence factors makes the Salmonella enterica serovar Typhimurium rfaH mutant a promising live-attenuated vaccine candidate.
Infect Immun. 2006 Oct;74(10):5914-25 [ Abstract ] [ PDF(0.71 MB) ] [ Supplementary data (3.8 Mb) ]

Mansson L.E., Melican K., Boekel J., Sandoval R.M., Hautefort I., Tanner G.A., Molitoris B.A., Richter-Dahlfors A. Real-time studies of the progression of bacterial infections and immediate tissue responses in live animals.
Cell Microbiol. 2007 Feb;9(2):413-24; [ Abstract ] [ PDF(1.23 MB) ] [ Movie S1 ] [ Movie S2 ]

Lucchini S., Rowley G., Goldberg M.D., Hurd D., Harrison M., Hinton J.C. H-NS mediates the silencing of laterally acquired genes in bacteria.
PLoS Pathog. 2006 Aug;2(8):e81. [ Abstract ] [ PDF(4 MB) ] [ Supplementary data (2.5 Mb) ]

Thompson A., Rolfe M.D., Lucchini S., Schwerk P., Hinton J.C., Tedin K. The bacterial signal molecule, ppGpp, mediates the environmental regulation of both the invasion and intracellular virulence gene programs of Salmonella.
J Biol Chem. 2006 Oct 6;281(40):30112-21. Epub 2006 Aug 11[ Abstract ] [ PDF(0.8 MB) ] [ Supplementary data S1 (2.6Mb) ] [ Supplementary data S2 (136Kb) ] [ Supplementary data S3 (134Kb) ] [ Supplementary data S5 (141Kb) ]

Greenacre E.J., Lucchini S., Hinton J.C., Brocklehurst T.F.The lactic acid-induced acid tolerance response in Salmonella enterica serovar Typhimurium induces sensitivity to hydrogen peroxide.
Appl Environ Microbiol. 2006 Aug;72(8):5623-5 [Abstract] [PDF(68 KB)] [Supplementary data (0.5 Mb ]

Mangan M.W., Lucchini S., Danino V., Croinin T.O., Hinton J.C., Dorman C.J.The integration host factor (IHF) integrates stationary-phase and virulence gene expression in Salmonella enterica serovar Typhimurium.
Mol Microbiol. 2006 Mar;59(6):1831-47. [ Abstract ] [PDF(0.24 MB) ] [ Supplementary data S1(1.0 Mb) ] [ Supplementary data S2 (82 Kb) ]

Ygberg S.E., Clements M.O., Rytkonen A., Thompson A., Holdne D.W., Hinton J.C., Rhen M. Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica.
Infect Immun. 2006 Feb;74(2):1243-54. [ Abstract ] [PDF(0.45 MB) ] [ Supplementary data S1 (1Mb) ]

Thompson A., Rowley G., Alston M., Danino V., Hinton J.C. Salmonella transcriptomics: relating regulons, stimulons and regulatory networks to the process of infection.
Curr Opin Microbiol. 2006 Feb;9(1):109-16. Epub 2006 Jan 18. Review [ Abstract ] [PDF(0.21MB) ]

Gantois .I, Ducatelle R., Pasmans F., Haesbrouck F., Thompson A., Hinton J.C., van Immerseel F. Butyrate specifically down-regulates Salmonella pathogenicity island 1 gene expression.
Appl Environ Microbiol. 2006 Jan;72(1):946-9 [ Abstract ] [PDF(74 KB) ]

2005

Nilsson A.I., Koskiniemi S., Eriksson S., Kugelberg E., Hinton J.C., Andersson D.I. Bacterial genome size reduction by experimental evolution.
Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12112-6. Epub 2005 Aug 12 [ Abstract ] [PDF(0.36 MB) ]

Ono S., Goldberg M.D., Olsson T., Esposito D., Hinton J.C., Ladbury J.E. H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.
Biochem J. 2005 Oct 15;391(Pt 2):203-13. [ Abstract ] [PDF(0.64 MB ) ]

Mills P.C., Richardson D.J., Hinton J.C., Spiro S. Detoxification of nitric oxide by the flavorubredoxin of Salmonella enterica serovar Typhimurium.
Biochem Soc Trans. 2005 Feb;33(Pt 1):198-9 [ Abstract ] [PDF(0.1 MB) ]

Lucchini S., Liu H., Jin Q., Hinton J.C., Yu J. Transcriptional adaptation of Shigella flexneri during infection of macrophages and epithelial cells: insights into the strategies of a cytosolic bacterial pathogen.
Infect Immun. 2005 Jan;73(1):88-102 [ Abstract ] [PDF(0.73 MB) ] [ Supplementary data S1 (2.0Mb) ] [ Supplementary data S2 (0.9 Mb) ] [ Supplementary data S3 (5.5 Mb) ]

2004

Gallant,C.V., Ponnampalam, T., Spencer, H., Hinton,J.C.D., Martin, N.L. H-NS Represses Salmonella enterica Serovar Typhimurium dsbA Expression during Exponential Growth
J. Bacteriol. 2004 Feb; 186(4): 910-918
[ Abstract ] [ PDF (0.93 Mb) ]

Walker, D., Rolfe, M., Thompson, A., Moore, G.R., James, R., Hinton, J.C., Kleanthous, C. Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversity. J. Bacteriol. 2004 Feb; 186(3): 866-869
[ Abstract ] [ PDF (0.55 Mb) ]

2003

Hautefort, I., Proenca, M.J., Hinton, J.C. Single copy GFP gene fusions allow accurate measurement of Salmonella gene expression in vitro and during infection of mammalian cells.
Appl. Environ. Microbiol. 2003 Dec; 69(12): 7480-7491
[ Abstract ] [ PDF (1.03 Mb) ]

Anjum, M.F., Lucchini, S., Thompson, A., Hinton, J.C., Woodward, M.J. Comparative genomic indexing reveals the phylogenomics of Escherichia coli pathogens.
Infect. Immun. 2003 Aug; 71(8), 4674-4683.
[ Abstract ] [ PDF (1.32 Mb) ]

Eriksson, S., Lucchini, S., Thompson, A., Rhen, M., Hinton, J.C. Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica
Mol Microbiol. 2003 jan.; 47(1): 103-118.
[ Abstract ] [ PDF (463 kb) ] [ Supplementary data S1 (1.5 Mb) ] [ Supplementary data S2 (0.5 Mb) ] [ Supplementary data S3 (1 Mb) ]

2002

Bongaerts, R.J., Hautefort, I., Sidebotham, J.M., and Hinton. J.C. Green fluorescent protein as a marker for conditional gene expression in bacterial cells.
Methods Enzymol. 2002; 358:43-66.
[ Abstract ] [ PDF (1.04 Mb) ]

Esposito, D., Petrovic, A., Harris, R., Ono, S., Eccleston, J.F., Mbabaali, A., Haq, I., Higgins CF, Hinton JC, Driscoll PC, Ladbury JE. H-NS oligomerization domain structure reveals the mechanism for high order self-association of intact protein.
J Mol Biol. 2002 Dec 6; 324(4):841-850.
[ Abstract ] [ PDF (1.16 Mb) ]

Clements M.O., Eriksson S., Thompson A., Lucchini S., Hinton J.C., Normark S., Rhen M. Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica.
Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8784-9.
[ Abstract ] [ PDF (344 kb) ] [ Supplementary data (335 kb) ]

Hautefort I., Hinton J.C. Molecular methods for monitoring bacterial gene expression during infection.
Methods in Microbiology. 2002; 31:55-90. Review.
[ Abstract ] [ PDF (452 kb) ]

2001

Goldberg M.D., Johnson M., Hinton J.C., Williams P.H.. Role of the nucleoid-associated protein Fis in the regulation of virulence properties of enteropathogenic Escherichia coli.
Mol Microbiol. 2001 Aug; 41(3):549-59.
[ Abstract ] [ PDF (1.51 Mb) ]

Lucchini S., Thompson A., Hinton J.C. Microarrays for microbiologists.
Microbiology. 2001 Jun; 147(Pt 6):1403-14. Review. No abstract available.
[ Abstract ] [ PDF (283 kb) ]

Clements M., Eriksson S., Tezcan-Merdol D., Hinton J.C., Rhen M. Virulence gene regulation in Salmonella enterica.
Ann Med. 2001 Apr; 33(3):178-85. Review.
[ Abstract ] [ PDF (90 kb) ]

Thompson A., Lucchini S., Hinton J.C. It's easy to build your own microarrayer!
Trends Microbiol. 2001 Apr; 9(4):154-6.
[ Abstract ] [ PDF (261 kb) ]

Renzoni D., Esposito D., Pfuhl M., Hinton J.C., Higgins C.F., Driscoll P.C., Ladbury J.E. Structural characterization of the N-terminal oligomerization domain of the bacterial chromatin-structuring protein, H-NS.
J Mol Biol. 2001 Mar 9; 306(5):1127-37.
[ Abstract ] [ PDF (351 kb) ]

Sonnenfield J.M., Burns C.M., Higgins C.F., Hinton J.C. The nucleoid-associated protein StpA binds curved DNA, has a greater DNA-binding affinity than H-NS and is present in significant levels in hns mutants.
Biochimie. 2001 Feb; 83(2):243-9.
[ Abstract ] [ PDF (1.43 Mb) ]

2000 and earlier

Hautefort I., Hinton J.C. Measurement of bacterial gene expression in vivo.
Philos Trans R Soc Lond B Biol Sci. 2000 May 29; 355(1397):601-11. Review.
[ Abstract ] [ PDF (460 kb) ]

Smyth C.P., Lundback T., Renzoni D., Siligardi G., Beavil R., Layton M., Sidebotham J.M., Hinton J.C., Driscoll P.C., Higgins C.F., Ladbury J.E. Oligomerization of the chromatin-structuring protein H-NS.
Mol Microbiol. 2000 May; 36(4):962-72.
[ Abstract ] [ PDF (490 kb) ]

Dorman C.J., Hinton J.C., Free A. Domain organization and oligomerization among H-NS-like nucleoid-associated proteins in bacteria.
Trends Microbiol. 1999 Mar; 7(3):124-8. Review.
[ Abstract ] [ PDF (156 kb) ]

Hinton J.C. The Escherichia coli genome sequence: the end of an era or the start of the FUN?
Mol Microbiol. 1997 Nov; 26(3):417-22. Review.
[ Abstract ] [ PDF (199 kb)]

Jordi B.J., Fielder A.E., Burns C.M., Hinton J.C., Dover N., Ussery D.W., Higgins C.F. DNA binding is not sufficient for H-NS-mediated repression of proU expression.
J Biol Chem. 1997 May 2; 272(18):12083-90.
[ Abstract ] [ PDF (389 kb)]