Theoretical Systems Biology
Modern molecular biology produces huge amounts of data covering all types of larger (DNA/RNA, proteins, carbohydrates, fats) and smaller molecules. The Theoretical Systems Biology (TSB) group studies structure, interactions and dynamics of all these molecules. New mathematical and computational approaches are being developed, helping to store, sort, integrate and analyse such data. Application of these methods improves understanding of the experimental systems studied in IFR and beyond.
Our research comprises genomics, transcriptomics, proteomics, and metabolomics. We are currently working on four topics:
- Modelling of subcellular systems, structural analyses and simulations.
- Computational analysis of natural products: 2d-structure analyses and analysis of structure-activity relationships.
- Data mining of large biological data sets, using our recently published new method for identification of significant substructures in data with no sequence information - the DASS algorithm. Development of a new tool DASS-GUI.
- Analysis of nucleotide sequences based on their physical properties. Development of a corresponding new genome browser.
Further information is available on the IFR Theoretical Systems Biology website.
Fax: +44(0)1603 507723 
