March 2007

SseL, a Salmonella deubiquitinase required for macrophage killing and virulence

IFR scientists have identified all the genes controlled by the important SsrAB virulence gene regulator in Salmonella. This has led to the publication of the discovery of a new type of Salmonella protein. It is an enzyme called SseL that helps Salmonella to survive inside macrophages, and to hijack the cell's defence strategy allowing the bacteria to spread throughout the body.

The work by Jay Hinton in collaboration with Professor David Holden of Imperial College, London was published in the prestigious journal PNAS. This and other recent discoveries confirm that IFR remains at the centre of Salmonella biology in Europe, and is playing an important role in determining how this dangerous bacterium causes human disease.

Salmonella typhimurium

SseL, a Salmonella deubiquitinase required for macrophage killing and virulence. Anne Rytkönen, John Poh, Junkal Garmendia, Cliona Boyle, Arthur Thompson, Mei Liu, Paul Freemont, Jay C. D. Hinton, and David W. Holden.

Published online before print February 20, 2007
Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0610095104

http://www.pnas.org/cgi/content/abstract/0610095104v1

 

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