Nathalie Juge
Research Leader
Research Area: Integrated Biology of GI Tract
Contact Details:
Institute of Food Research,
Norwich Research Park,
Colney, Norwich,
NR4 7UA
UK
nathalie.juge@ifr.ac.uk
Research interests
- Research area: the role of mucus in intestinal host-bacteria homeostasis
- Special interests: structure-function studies of (1) bacterial adhesins involved in mucus regognition and protein-glycan interactions (2) glycosidases involved in oligo- and polysaccharides and mucus-degradation (3) the intestinal mucus layer (expression, thickness, glycosylation) and impact of host and bacteria on mucus properties using ex vivo intestinal and in vivo mouse models.
- Participating Investigator of the Consortium for Functional Glycomics
- Steering Committee member of Glycosciences in Norwich- GlycoNOW
- Scientific organisor of the Royal Society Chemistry Carbohydrate Group Meeting- Sugars in Norwich, 15-16 Sept 2009, IFR, Norwich and the 5th European Symposium on Enzymes in Grain Processing held in Norwich 31 March-2nd April 2008.
Selected Publications
Tison M., André-Leroux G., Lafond M., Georis J., Juge N., Berrin J. G. (2009)
Molecular determinants of substrate and inhibitor specificities of the penicillium griseofulvum family 11 xylanases
Biochimica et Biophysica Acta - Proteins and Proteomics. 1794 (3) 438-445
Molecular determinants of substrate and inhibitor specificities of the penicillium griseofulvum family 11 xylanases
Biochimica et Biophysica Acta - Proteins and Proteomics. 1794 (3) 438-445
Andre-Leroux G., Berrin J. G., Georis J., Arnaut F., Juge N. (2008)
Structure-based mutagenesis of Penicillium griseofulvum xylanase using computational design
Proteins: Structure, Function, and Bioinformatics 72 (4) 1298-1307
Structure-based mutagenesis of Penicillium griseofulvum xylanase using computational design
Proteins: Structure, Function, and Bioinformatics 72 (4) 1298-1307
Recent Publications
Berthiller F., Krska R., Domig K. J., Kneifel W., Juge N., Schuhmacher R., Adam G. (2011)
Hydrolytic fate of deoxynivalenol-3-glucoside during digestion
Toxicology Letters 206 (3) 264-267
Hydrolytic fate of deoxynivalenol-3-glucoside during digestion
Toxicology Letters 206 (3) 264-267
Frese S. A., Benson A. K., Tannock G. W., Loach D. M., Kim J., Zhang M., Oh P. L., Heng N. C. K., Patil P. B., Juge N., MacKenzie D. A., Pearson B. M., Lapidus A., Dalin E., Tice H., Goltsman E., Land M., Hauser L., Ivanova N., Kyrpides N. C., Walter W. (2011)
The evolution of host specialization in the vertebrate gut symbiont Lactobacillus reuteri
PLoS Genetics 7 (2) 1001314
DOI:10.1371/journal.pgen.1001314
The evolution of host specialization in the vertebrate gut symbiont Lactobacillus reuteri
PLoS Genetics 7 (2) 1001314
DOI:10.1371/journal.pgen.1001314
Heavens D., Tailford L. E., Crossman L., Jeffers F., MacKenzie D. A., Caccamo M., Juge N. (2011)
Genome sequence of the vertebrate gut symbiont Lactobacillus reuteri ATCC 53608
Journal of Bacteriology 193 (15) 4015-4016
Genome sequence of the vertebrate gut symbiont Lactobacillus reuteri ATCC 53608
Journal of Bacteriology 193 (15) 4015-4016
Jeffers F., Fuell C., Tailford L. E., MacKenzie D. A., Bongaerts R., Juge N. (2010)
Mucin-lectin interactions assessed by flow cytometry
Carbohydrate Research 345 (10) 1486-1491
DOI:10.1016/j.carres.2010.05.012
Mucin-lectin interactions assessed by flow cytometry
Carbohydrate Research 345 (10) 1486-1491
DOI:10.1016/j.carres.2010.05.012
Mackenzie D. A., Jeffers F., Parker M. L., Vibert-Vallet A., Bongaerts R. J., Roos S., Walter J., Juge N. (2010)
Strain-specific diversity of mucus-binding proteins in the adhesion and aggregation properties of lactobacillus reuteri
Microbiology 156 (11 Sp. Iss. S1) 3368-3378
DOI:10.1099/mic.0.043265-0
Strain-specific diversity of mucus-binding proteins in the adhesion and aggregation properties of lactobacillus reuteri
Microbiology 156 (11 Sp. Iss. S1) 3368-3378
DOI:10.1099/mic.0.043265-0
Fax: +44(0)1603 507723 
