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Nathalie Juge

Research Leader

Research Area: Integrated Biology of GI Tract

Contact Details:

Institute of Food Research,
Norwich Research Park,
Colney, Norwich,
NR4 7UA
UK
nathalie.juge@bbsrc.ac.uk

Research interests

  • Research area: the role of mucus in intestinal host-bacteria homeostasis
  • Special interests:  structure-function studies of (1) bacterial adhesins involved in mucus regognition and protein-glycan interactions (2) glycosidases involved in oligo- and polysaccharides and mucus-degradation (3) the colonic mucus layer (expression, thickness, glycosylation) during ageing or gut-related diseases
  • Member of the editorial advisory board of current enzyme inhibition
  • Representative on the management committee of Cost action 928 on "the control and exploitation of enzymes for added-value food production (2006-2010)
  • Participating Investigator of the Consortium for Functional Glycomics
  • Steering Committee member of Glycosciences in Norwich- GlycoNOW
  • Scientific organisor of the Royal Society Chemistry Carbohydrate Group Meeting- Sugars in Norwich, 15-16 Sept 2009, IFR, Norwich and the 5th European Symposium on Enzymes in Grain Processing held in Norwich 31 March-2nd April 2008.

Selected Publications

Tison M., André-Leroux G., Lafond M., Georis J., Juge N., Berrin J. G. (2009)
Molecular determinants of substrate and inhibitor specificities of the penicillium griseofulvum family 11 xylanases
Biochimica et Biophysica Acta - Proteins and Proteomics. 1794 (3) 438-445
Andre-Leroux G., Berrin J. G., Georis J., Arnaut F., Juge N. (2008)
Structure-based mutagenesis of Penicillium griseofulvum xylanase using computational design
Proteins: Structure, Function, and Bioinformatics 72 (4) 1298-1307

Recent Publications

Jeffers F., Fuell C., Tailford L. E., MacKenzie D. A., Bongaerts R., Juge N. (2010)
Mucin-lectin interactions assessed by flow cytometry
Carbohydrate Research 345 (10) 1486-1491
DOI:10.1016/j.carres.2010.05.012
Elliott G., Durand A., Hughes R. K., D'Ovidio R., Juge N. (2009)
Isolation and characterisation of a xylanase inhibitor Xip-II gene from durum wheat
Journal of Cereal Science 50 (3 (esEGP5 Special Issue)) 324-331
MacKenzie D. A., Tailford L. E., Hemmings A., Juge N. (2009)
Crystal structure of a mucus binding protein repeat reveals an unexpected functional immunoglobulin binding activity.
Journal of Biological Chemistry 284 (47) 32444-32453
DOI:10.1074/jbc.M109.040907
Berrin J. G., Juge N. (2008)
Factors affecting xylanase functionality in the degradation of arabinoxylans
Biotechnology Letters 30 (7) 1139-1150
Hmidet N., Bayoudh A., Nasri M., Berrin J. G., Kanoun S., Juge N. (2008)
Purification and biochemical characterization of a novel alpha-amylase from Bacillus licheniformis NH1 - Cloning, nucleotide sequence and expression of amyN gene in E. coli
Process Biochemistry 43 (5) 499-510
Vardakou M. , Dumon C. , Flint J. , Murray J. , Christakopoulos P. , Weiner D. , Juge N. , Lewis R. , Gilbert H. J. (2008)
Understanding the structural basis for substrate and inhibitor recognition in Eukaryotic GH11 xylanases
Journal of Molecular Biology 375 1293-1305

Dr Nathalie Juge

    Related links

    Career details

    • 1989-1993 PhD in Biochemistry-Molecular Biology of Nutrition “Molecular and Cellular Aspects”, Aix-Marseille III University, Marseille, France
    • 1994-1995 Post-doctoral fellow (EMBO grant and EU contract) at Department of Chemistry, Carlsberg Laboratory, Copenhagen, Denmark
    • 1995-1996 Post-doctoral fellow (EU contract) at Institut de Biologia Fonamental (IBF) Universitat Autonoma de Barcelona, Spain
    • 1996-1997 Post-doctoral fellow (EU Marie Curie grant) at IFR, Norwich, UK
    • 1997-1999 Lecturer in Biochemistry/Molecular Biology, University Paul Cézanne Marseille, France
    • 1999-2004 Head of the “Glycosidase” Team at IFR, Norwich, UK
    • 2005-2007 Head of the IMAG Team (Engineering and Mechanism of Action of Glycosidases) at BiosCiences (CNRS), Marseille, France
    • From 2007 Honory Lecturer, Paul Cézanne University, Marseille, France
    • From 2007 Head of the “Glycobiome and Diet” Group at IFR, Norwich, UK
    • From 2008 Deputy Head of the “Integrated Biology of the Gastrointestinal Tract” Institute Strategic Programme at IFR, Norwich, UK