Career-track Research Leader
Institute of Food Research,
Norwich Research Park,
Understanding the mechanisms by which dietary factors, inflammation and the gut microflora drive aberrant CpG island methylation leading to neoplasia in the gastrointestinal tract.
Using CpG island methylation as predictive biomarkers for risk of neoplastic progression.
New evidence for epigenetic effects of diet in healthy ageing
06 Dec 2012
New research in human volunteers has shown that molecular changes to our genes, known as epigenetic marks, are driven mainly by ageing but are also affected by what we eat. The study showed that whilst age had the biggest effects on these molecular changes, selenium and vitamin D status reduced the accumulation of epigenetic changes, […] Read full story
Epigenetics, folates and the human gut
09 May 2012
IFR is exploring epigenetic changes in cells that line the human gut, which are linked to our vulnerability to developing cancer. Here, Professor Ian Johnson comments on DNA methylation, and on a new study from Nigel Belshaw’s group which suggests that prolonged exposure to increased, supra-nutritional doses of folic acid may cause these epigenetic changes […] Read full story
Procyanidin Induces Apoptosis of Esophageal Adenocarcinoma Cells via JNK Activation of c-Jun.
Nutrition and Cancer 66 (2) 335-41
Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro.
European Journal of Nutrition 52 1327-1341
Quantitative profiling of CpG island methylation in human stool for colorectal cancer detection
International Journal of Colorectal Disease 28 (1) 35-42
The bioactivity of modified pectin fragments
Bioactive Carbohydrates and Dietary Fibre 1 (1) 21-37
Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa
Aging Cell 12 (1) 148-155
TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death
Biochimica et Biophysica Acta - Molecular Cell Research 1823 (10) 1914-1924
Postgraduate Symposium Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention
Proceedings of the Nutrition Society 71 (2) 237-245
Supra-physiological folic acid concentrations induce aberrant DNA methylation in normal human cells in vitro
Epigenetics 7 (7) 689-694
Can the rat be used as a valid model of human esophageal adenocarcinoma?
Diseases Of The Esophagus 25 (2) 159-165
Pectin - An emerging new bioactive food polysaccharide
Trends in Food Science and Technology 24 (2) 64-73