Paul Kroon

Research Leader

Research Area: Plant Natural Products and Health

Contact Details:

Institute of Food Research,
Norwich Research Park,
Colney, Norwich,
NR4 7UA
UK
paul.kroon@ifr.ac.uk

Research interests

Undertaking research on the intake, absorption, metabolism and health effects of dietary polyphenols with a focus on linking the metabolism that occurs during absorption to the biological effects of the metabolites, and the impact of ingesting polyphenol-rich foods/beverages on cardiovascular disease risk.

Particular interests include: the mechanisms of absorption from the gut; the identification and quantification of polyphenol metabolites in human plasma and urine; mechanisms of action at the cellular level (particularly in relation to gene expression patterns, signalling pathways, vascular function and inflammation); clinical trials to assess effects of consumption on established and emerging biomarkers integrated with omics approaches.

Selected Publications

Radreau P., Rhodes J. D., Mithen R. F., Kroon P. A., Sanderson J. (2009)
Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells
Experimental Eye Research 89 (6) 995-1002
DOI:10.1016/j.exer.2009.08.011

Recent Publications

Al-Shalmani S., Suri S., Hughes D. A., Kroon P. A., Needs P. W., Taylor M. A., Tribolo S., Wilson V. G. (2011)
Quercetin and its principal metabolites, but not myricetin, oppose LPS-induced hyporesponsiveness of the porcine isolated coronary artery.
British Journal of Pharmacology 162 (7) 1485-1497
DOI:10.1111/j.1476-5381.2010.00919.x

Mateos R., Pereira-Caro G., Bravo L., Saha S., Cert R., Redondo-Horcajo M., Kroon P. A. (2011)
Acetylation of hydroxytyrosol enhances its transport across differentiated caco-2 cell monolayers
Food Chemistry 125 (3) 865-872

Ostertag L. L., O'Kennedy N., Kroon P. A., Duthie G. G., de Roos B. (2011)
In vitro and ex vivo anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations
Molecular Nutrition and Food Research 54 60-81

Plumb J. A., Rhodes M. J. C., Lampi A. M., Buchgraber M., Kroon P. A. (2011)
Phytosterols in plant foods: exploring contents, data distribution and aggregated values using an online bioactives database.
Journal of Food Composition and Analysis 24 (7) 1024-1031
DOI:doi:10.1016/j.jfca.2010.10.007

Arts I. C. W., Bartholomé R., Hollman P. C. H., Bast A., Dagnelie P. C., Roos D., Keijer J., Kroon P. A., Needs P. W., Gaenen G. (2010)
The deconjugation kinetics of glucuronidated phase-2 flavonoid metabolites by β-glucuronidase from neutrophils.
Drug metabolism and Pharmacokinetics 25 (4) 379-387

Finglas P. M., Plumb J., Kroon P., Kierly M., Black L. J., Larsen J. C., Speijers G. J., Kapsokefalou M., Sheehan D. (2010)
EuroFIR eBASIS: application for health claims submissions and evaluations
European Journal of Clinical Nutrition 64 (Supplement 3) S101 to S107

Kiely M., Black L., Plumb J. A., Kroon P. A., Hollman P. C., Larsen J. C., Speijers G. J., Kapsokefalou M., Sheehan D., Gry J., Finglas P. M. F. (2010)
Eurofir eBASIS (Bioactive Substances in Food Information System):application for health claims submissions and evaluations
European Journal of Clinical Nutrition 64 (3) S101-107

Kroon P. A., Iyer I., Chunduri P., Chan V., Brown L. (2010)
The cardiovascular nutrapharmacology of resveratrol: pharmacokinetics, molecular mechanisms and therapeutic potential
Current Medicinal Chemistry 17 (23) 2442-2455

Ostertag L. M., O'Kennedy N., Kroon P. A., Duthie G. G., de Roos B. (2010)
Impact of dietary polyphenols on human platelet function - a critical review of controlled dietary intervention studies
Molecular Nutrition and Food Research 54 (1) 60-81

Scalbert A., Andres-Lacueva C., Arita M., Kroon P. A., Manach C., Urpi-Sarda M., Wishart D. (2010)
Databases on food phytochemicals and their health promoting effects
Journal of Agricultural and Food Chemistry 59 (9) 4331-4348

Soler A., Romero M. P., Saha S., Furniss C. M., Kroon P. A., Motilva M. J. (2010)
Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human small intestinal epithelial CaCo2/tc7 cell line
Food Chemistry 119 (2) 703-714

Suri S., Liu X. H., Rayment S., Hughes D. A., Kroon P. A., Needs P. W., Taylor M. A., Tribolo S., Wilson V. G. (2010)
Quercetin and its major matabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery
British Journal of Pharmacology 159 (3) 566-575