Richard Mithen

Programme Leader

Contact Details:

Institute of Food Research,
Norwich Research Park,
Colney, Norwich,
NR4 7UA
UK
richard.mithen@ifr.ac.uk

Research interests

The role of dietary phytochemicals in maintaining and promoting health, and prevention the oset and progression of chronic disease

The biology of glucosinolates

Broccoli

Selected Publications

Chambers K. F., Bacon J. R., Kemsley E. K., Mills R., Ball R., Mithen R. F., Traka M. (2009)
Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure
Prostate 69 (13) 1411-1421
DOI:10.1002/pros.20986

Recent Publications

Melchini A., Traka M. H., Catania S., Miceli N., Taviano M. F., Maimone P., Francisco M., Mithen R., Costa C. (2013)
Antiproliferative activity of the dietary isothiocyanate erucin, bioactive compound from cruciferous vegetables, on human prostate cancer cells
Nutrition and Cancer:An International Journal 65 (1) 132-138

Traka M. H., Saha S., Huseby S., Kopriva K., Walley P. G., Barker G. C., Moore J., van den Bosch F., Constant H., Kelly L., Schepers H., Boddupalli S., Mithen R. (2013)
Genetic regulation of glucoraphanin in Beneforte broccoli
New Phytologist 198 (4) 1085-1095
DOI:10.1111/nph.12232

Huseby S., Koprivora A., Bok-Rye L., Saha S., Mithen R., Wold A., Bengtsson G. B., Kopriva S. (2012)
Diurnal and light regulation of sulfur assimilationand glucosinolate biosynthesis in Arabidopsis
Journal of Experimental Botany 64 (4) 1039-1048

Lee B. R., Huseby S., Koprivova A., Chetelat A., Wirtz M., Mugford S. T., Navid E., Brearley C., Saha S., Mithen R., Hell R., Farmer E. E., Kopriva A. (2012)
Effects of fou8/fry1 mutation on sulfur metabolism. Is decreased internal sulfate the trigger of sulfate starvation response?
PLoS ONE xxxxxxxxxxx xxxxxxxxxx
DOI:PONE-D-12-01548R2

Lee B. R., Huseby S., Koprivova A., Chételat A., Wirtz M., Mugford S. T., Navid E., Brearley C., Saha S., Mithen R., Hell R., Farmer E. E., Kopriva S. (2012)
Effects of fou8/fry1 mutation on sulfur metabolism: is decreased internal sulfate the trigger of sulfate starvation response?
PLoS ONE 7 (6) e39425
DOI:10.1371/journal.pone.0039425

Melchini A., Needs P., Mithen R., Traka M. (2012)
Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate
Journal of Medicinal Chemistry 55 (22) 9682-9692

Saha S., Hollands W. J., Teucher T., Needs P. W., Narbad A., Ortori C. A., Barrett D. A., Rossiter J. T., Mithen R. F., Kroon P. A. (2012)
Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli
Molecular Nutrition and Food Research 56 (12) 1906-1916

Traka M. H., Mithen R. F. (2011)
Plant science and human nutrition: challenges in assessing health-promoting properties of phytochemicals.
Plant Cell 23 (7) 2483-97
DOI:10.1105/tpc.111.087916