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Richard Mithen

Programme Leader

Contact Details:

Institute of Food Research,
Norwich Research Park,
Colney, Norwich,
NR4 7UA
UK
richard.mithen@ifr.ac.uk

Research interests

The role of dietary phytochemicals in maintaining and promoting health, and prevention the oset and progression of chronic disease

The biology of glucosinolates

 Broccoli

News articles

Movember comes to the IFR & the Mo-rwich Research Park
12 Nov 2013
MO13 Primary Logo Stacked POS copyThe Institute of Food Research is once again supporting Movember with a twenty strong team of Mo Bros sprouting facial hair, with support from Mo Sistas, to help raise funds and awareness of men’s health issues. Many of the IFR Mo Team are actively involved in research into how diet affects men’s health. Mo-fessor Richard […] Read full story

Eating broccoli retunes metabolism
31 Jul 2013
_DSC0270Researchers at the Institute of Food Research have obtained the first evidence from human studies of how diets rich in glucosinolates, such as glucoraphanin found in broccoli, can ‘re-tune’ cellular processes that get disrupted as we age. Retuning these processes to normal may contribute to the reduced risk of cancer seen in people who eat […] Read full story

Reliably higher levels of healthy compound in Beneforté broccoli
10 Apr 2013
HG broccoli glucoraphaninField trials and genetic studies have shown that a new variety of broccoli reliably yields higher levels of a health-promoting compound. Broccoli contains a compound called glucoraphanin, which has been shown to promote health by maintaining cardiovascular health and a reduction in the risk of cancer. A long term breeding programme to increase glucoraphanin levels […] Read full story

Video: An introduction to IFR’s research into bioactive food components
25 Mar 2013
_DSC9749Plant bioactives are chemicals that give plant foods their colour, taste and smell. By eating these compounds in relatively low amounts they are very good at keeping us healthy as they have a range of interesting biological activities. In this video, Professor Richard Mithen gives an overview of our research in this area explaining why […] Read full story

Young scientists showcase their research
25 Mar 2013
NSEW 2013 RGBAs part of National Science & Engineering Week, four postgraduate students from the Institute of Food Research and the John Innes Centre, presented their research to an appreciative audience. Research topics covered purple foods and heart disease, the wild west inside our guts, antibiotics from insect bacteria and sticky bacteria. Watch the presentations Purple up […] Read full story

Video introduction to the IFR’s Food and Health research programme
30 Jan 2013
Professor Richard MithenFood is of fundamental importance to our health, and understanding exactly how foods keep us healthy is the overarching aim of the Food and Health strategic programme at the Institute of Food Research. In this video, Professor Richard Mithen gives an overview of this BBSRC-funded programme. What are the key components in foods that keep […] Read full story

IFR supporting NutraFormulate Conference
18 Jan 2013
nutraformulatelogoIFR is pleased to support NutraFormulate – Ingredients for Healthy Living, which will be held at the NMM Exhibition Centre, Birmingham, 20-21  March 2013. Richard Mithen and Paul Kroon from the Institute of Food Research will be speaking at NutraFormulate – Ingredients for Healthy Living Food for Thought Conference in March 2013. The Food & Health […] Read full story

Major award to study protective effects of broccoli consumption against prostate cancer
04 Sep 2012
The Prostate Cancer Foundation is providing $1M of funding to the Institute of Food Research and the University of East Anglia (UEA) to study the protective effects of broccoli consumption against prostate cancer. It builds upon several years of research led by Professor Richard Mithen on the biological activity of a naturally occurring compound called […] Read full story

Selected Publications

Chambers K. F., Bacon J. R., Kemsley E. K., Mills R., Ball R., Mithen R. F., Traka M. (2009)
Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure
Prostate 69 (13) 1411-1421
DOI:10.1002/pros.20986

Recent Publications

Armah C. N., Traka M. H., Dainty J. R., Defernez M., Janseens A., Leung W., Doleman J. F., Potter J. F., Mithen R. F. (2013)
A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolic profiles by modulating mitochondrial function
American Journal of Clinical Nutrition
Traka M. H., Saha S., Huseby S., Kopriva K., Walley P. G., Barker G. C., Moore J., van den Bosch F., Constant H., Kelly L., Schepers H., Boddupalli S., Mithen R. (2013)
Genetic regulation of glucoraphanin accumulation in Beneforté broccoli.
New Phytologist 198 (4) 1085-95
DOI:10.1111/nph.12232
Huseby S., Koprivora A., Bok-Rye L., Saha S., Mithen R., Wold A., Bengtsson G. B., Kopriva S. (2012)
Diurnal and light regulation of sulfur assimilationand glucosinolate biosynthesis in Arabidopsis
Journal of Experimental Botany 64 (4) 1039-1048
Lee B. R., Huseby S., Koprivova A., Chetelat A., Wirtz M., Mugford S. T., Navid E., Brearley C., Saha S., Mithen R., Hell R., Farmer E. E., Kopriva A. (2012)
Effects of fou8/fry1 mutation on sulfur metabolism. Is decreased internal sulfate the trigger of sulfate starvation response?
PLoS ONE xxxxxxxxxxx xxxxxxxxxx
Lee B. R., Huseby S., Koprivova A., Chételat A., Wirtz M., Mugford S. T., Navid E., Brearley C., Saha S., Mithen R., Hell R., Farmer E. E., Kopriva S. (2012)
Effects of fou8/fry1 mutation on sulfur metabolism: is decreased internal sulfate the trigger of sulfate starvation response?
PLoS ONE 7 (6) e39425
DOI:10.1371/journal.pone.0039425
Melchini A., Needs P., Mithen R., Traka M. (2012)
Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate
Journal of Medicinal Chemistry 55 (22) 9682-9692
Saha S., Hollands W. J., Teucher T., Needs P. W., Narbad A., Ortori C. A., Barrett D. A., Rossiter J. T., Mithen R. F., Kroon P. A. (2012)
Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli
Molecular Nutrition and Food Research 56 (12) 1906-1916

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