Sacha Lucchini
Career-track Research Leader
Contact Details:
Institute of Food Research,
Norwich Research Park,
Colney, Norwich,
NR4 7UA
UK
sacha.lucchini@ifr.ac.uk
Research interests
My research is aimed at identifying and characterising bacterial genes important for colonisation of the lower gastrointestinal (GI) tract. More specifically, we are currently looking at finding functions that are specifically required for the adaptation of the model organism Escherichia coli to the inflamed intestine.
Selected Publications
Pfeiffer V., Papenfort K., Lucchini S., Hinton J. C. D., Vogel J. (2009)
Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation
Nature Structural and Molecular Biology 16 (8) 840-846
DOI:10.1038/nsmb.1631
Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation
Nature Structural and Molecular Biology 16 (8) 840-846
DOI:10.1038/nsmb.1631
Recent Publications
Rolfe M. D., Rice C. J., Lucchini S., Pin C., Thompson A., Cameron A., Alston M., Stringer M. F., Betts R. P., Baranyi J., Peck M. W., Hinton J. C. D. (2012)
Lag phase is a distinct growth phase that prepares bacteria for exponential growth and involves transient metal accumulation
Journal of Bacteriology 194 (3) 686-701
Lag phase is a distinct growth phase that prepares bacteria for exponential growth and involves transient metal accumulation
Journal of Bacteriology 194 (3) 686-701
Alston M., Seers J., Hinton J. C. D., Lucchini S. (2010)
BABAR: an R package to simplify the normalisation of common reference design microarray-based transcriptomic datasets
BMC Bioinformatics 11 73
DOI:10.1186/1471-2105-11-73
BABAR: an R package to simplify the normalisation of common reference design microarray-based transcriptomic datasets
BMC Bioinformatics 11 73
DOI:10.1186/1471-2105-11-73
Dillon S., Cameron A., Hokamp K., Lucchini S., Hinton J. C., Dorman C. (2010)
Genome-wide analysis of the H-NS and Sfh regulatory networks in Salmonella Typhimurium identifies a plasmid-encoded transcription silencing mechanism
Molecular Microbiology 76 (5) 1250-1265
Genome-wide analysis of the H-NS and Sfh regulatory networks in Salmonella Typhimurium identifies a plasmid-encoded transcription silencing mechanism
Molecular Microbiology 76 (5) 1250-1265
King T., Lucchini S., Hinton J. C. D., Gobius K. (2010)
Transcriptomic analysis of Escherichia coli O157:h7 and K-12 cultures exposed to inorganic and organic acids in stationary phase reveals acidulant and strain-specific acid tolerance responses
Applied and Environmental Microbiology 76 (19) 6514-6528
Transcriptomic analysis of Escherichia coli O157:h7 and K-12 cultures exposed to inorganic and organic acids in stationary phase reveals acidulant and strain-specific acid tolerance responses
Applied and Environmental Microbiology 76 (19) 6514-6528
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