Prof. Arjan Narbad
WebsiteFood Safety Centre
My research interests are focused on the microbial ecology of the gastrointestinal tract and the role of the complex gut microbiota in health and disease.
I have a particular interest in the isolation and characterisation of gut commensal bacteria of animal and human origin for use as probiotics for exclusion of gut pathogens. Mechanisms of competitive exclusion phenomena are being investigated with the objective of designing strains with improved functionality.
I am interested in identifying and characterising novel antimicrobials (including bacteriophage endolysins) that target gut pathogens such as Clostridium difficile and Clostridium perfringens, and the impact of these biomolecules on the gut microbial communities is another area of active research within my group.
The effect of dietary components on the gut microbial ecology and the importance of gut commensals in transformation of food bioactive molecules are being studied using in vitro model gut systems as well in vivo with human volunteers.
Korean journal for food science of animal resources 37 p147-152
Publisher’s version: 10.5851/kosfa.2017.37.1.147
Genome Announcements 2017 vol. 5 no. 7 pe01528-16
Publisher’s version: 10.1128/genomeA.01528-16
Potential of Lactobacillus plantarum CCFM639 in Protecting against Aluminum Toxicity Mediated by Intestinal Barrier Function and Oxidative Stress
Nutrients 8 p783
Publisher’s version: 10.3390/nu8120783
Identifying crop variants with high resistant starch content to maintain healthy glucose homeostasis
Nutrition Bulletin 41 p372-377
Publisher’s version: 10.1111/nbu.12240
Intestinal PPARgamma signaling is required for sympathetic nervous system activation in response to caloric restriction
Scientific Reports 6 p36937
Publisher’s version: 10.1038/srep36937
Current Microbiology 73 p442-51
Publisher’s version: 10.1007/s00284-016-1079-8
Microbial biotechnology 9 p496-501
Publisher’s version: 10.1111/1751-7915.12314
Genome announcements 4 pe00481-16
Publisher’s version: 10.1128/genomeA.00481-16
Molecular metabolism (2016) 1 6 p1-6
Publisher’s version: doi:10.1016/j.molmet.2016.06.006
Bidirectional communication between the gut microbiome and the Aryl-Hydrocarbon-Receptor (AhR) influences host energy homeostasis as well as microbiome composition in the small intestine
npj Biofilms and Microbiomes 27 p16014
Publisher’s version: doi:10.1038/npjbiofilms.2016.14
Crystal Structure of the CTP1L Endolysin Reveals How Its Activity Is Regulated by a Secondary Translation Product.
Journal of Biological Chemistry 291 p4882-93
Publisher’s version: 10.1074/jbc.M115.671172
Lipid Technology 27 p179-182
Publisher’s version: 10.1002/lite.201500035
A treatment programme for Clostridium difficile (C.diff) was announced this week during International Infection Prevention Awareness Week 17-21 October.more +
A collaboration between the NNUH and IFR has been crucial to the success of the Faecal Microbiota Transplants (FMT) to combat Clostridium difficile infectionmore +
The Institute of Food Research and Jiangnan University have collaborated to initiate a UK-China Joint Centre for Probiotic Research.more +
Research has revealed how viruses called bacteriophages destroy the bacterium Clostridium difficile, which is becoming a serious problem in hospitals and healthcare institutes, due to its resistance to antibiotics.more +
IFR researchers have characterised the coat of a potential poultry probiotic, giving the first clues of how it may be used to exclude pathogenic bacteria from chickens.more +