Dr Carmen Pin
WebsiteDecrypting the Villus
I am interested in the effective integration of experimental and theoretical approaches to advance the understanding of biological processes that take place in the gastrointestinal tract.
The gastrointestinal tract forms a major organ for the absorption of compounds from the intestinal lumen and for the defence against pathogenic agents. Important elements interacting in the GI tract are epithelium, mucosal immune system and bacteria. We are investigating these elements and their interactions by combining theoretical models with experimental results.
The intestinal epithelium is subjected to a constant renewal process forming a barrier between the body and the gut content and thus continuously exposed to internal and foreign stimuli. We are complementing experimental approaches that capture the response of the epithelium in normal and altered conditions with computational and theoretical models for hypothesis testing, generation of predictions and estimation of parameters.
The gut microbiota is a complex microbial system that affects both mucosal immune system and epithelium. The composition of the gut microbiota is determined by interactions with the host and diet and within the microbial community. Microbial responses in the gut environment are being studied by comparing experimental results with the output of theoretical approaches that assume different mechanisms of interaction.
Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi
The FASEB Journal 31 p636-649
Publisher’s version: 10.1096/fj.201601002
Evidence of metabolically active but non-culturable Listeria monocytogenes in long-term growth at 10 °C. Research Microbiology. S0923-2508(16)00008-5.
Research in Microbiology 16 pS0923-2508(16)00008-5
Publisher’s version: 10.1016/j.resmic.2016.01.003
Scientific Reports 6 p21923
Publisher’s version: 10.1038/srep21923