Prof. Claudio Nicoletti
WebsiteGut Health and Food Safety Programme
My main interest is in understanding the complex interplay between the intestinal epithelium and immune system, with emphasis on dendritic cells (DC), and how these help in establishing and maintaining the correct intestinal immune homeostasis.
Building on our key observation that epithelial cells influence mucosal DC mobilisation and function in the intestine, our work aims to define the molecular basis of intestinal epithelial cell-DC interactions and their biological consequences for epithelial barrier function, gut health and immunity. Our work has established that these interactions are critical to generate rapid, effective and finely tuned mucosal and systemic immune response to food-borne pathogens and food components.
This work is paralleled by the investigation of the role of probiotics in the regulation of mucosal immune responses and their potential in suppressing allergic reactions and as delivery vectors for therapeutics. Our approach encompasses the use a wide variety of in vitro organ and mixed cell culture systems and in vivo transgenic (including germ free) mouse models in conjunction with imaging modalities.
Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults
Clinical Nutrition p1-9
Publisher’s version: 10.1016/j.clnu.2015.12.003
Expert Review Gastroenterology and Hepathology 22 p1-3
Publisher’s version: 10.1586/17474124.2015.1092872
Age-associated modifications of intestinal permeability and innate immunity in the human small intestine
Clinical Science 129 p515-527
Publisher’s version: 10.1042/CS20150046
Development of a Hypoallergenic Recombinant Parvalbumin for First-in-Man Subcutaneous Immunotherapy of Fish Allergy.
International Archives of Allergy & Immunology 166 p41-51
Publisher’s version: 10.1159/000371657
A new study has found that selenium supplementation can have positive and negative effects on our immune systemmore +
Scientists and clinicians on the Norwich Research Park have carried out the first detailed study of how our intestinal tract changes as we age, and how this determines our overall healthmore +
A study has shown that a daily probiotic drink changed how cells lining the nasal passages of hay fever sufferers reacted to a single out-of-season challenge. However, it did not lead to significant changes in hay fever symptoms, although this challenge test may not have accurately represented natural allergen exposure.more +