Dr Norihito Kawasaki
WebsiteMEDPOL “Molecular Dissection of Immunomodulatory Function of Polysaccharides”
Our group investigates the role of glycan-binding proteins (GBPs) that recognize glycans also known as carbohydrates or saccharides and mediate immune responses. We aim to understand how interaction between GBPs and glycans impacts on our health and exploit such function of GBPs to treat and/or prevent human diseases.
Current research focuses on the discovery of dietary polysaccharides that bind to GBPs and modulate immune responses. While such “immunomodulatory” polysaccharides have been proposed as healthcare supplements, the mechanism by which they elicit their functions remains to be addressed. Our research is at the interface of immunology and glycobiology, and employs multidisciplinary methodologies of immunology, molecular biology, and chemistry.
Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.
Journal of Biological Chemistry 291 p17629-38
Publisher’s version: 10.1074/jbc.M116.741256
Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptors
Frontiers in Microbiology, section Microbial Immunology 8 p321
Publisher’s version: 10.3389/fmicb.2017.00321
Biochem Biophys Res Commun 479 p1-4
Publisher’s version: 10.1016/j.bbrc.2016.08.055
Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man.
Journal of Biological Chemistry 290 p30066-77
Publisher’s version: 10.1074/jbc.M115.691337
A new study has found a novel way in which certain bacteria are recognised and trigger our immune system.more +
1999 - 2003 B.Sc. in Chemical engineering, Nagoya University, Japan
2003 - 2005 M.Sc. in Bioscience, The University of Tokyo, Japan
2005 - 2008 Ph.D. in Bioscience, The University of Tokyo, Japan
2008 - 2013 Postdoctoral fellow, The Scripps Research Institute
2013 - Career-track Research Leader, The Institute of Food Research