Dr Norihito Kawasaki
WebsiteMEDPOL “Molecular Dissection of Immunomodulatory Function of Polysaccharides”
Our group investigates the role of glycan-binding proteins (GBPs) that recognize glycans also known as carbohydrates or saccharides and mediate immune responses. We aim to understand how interaction between GBPs and glycans impacts on our health and exploit such function of GBPs to treat and/or prevent human diseases.
Current research focuses on the discovery of dietary polysaccharides that bind to GBPs and modulate immune responses. While such “immunomodulatory” polysaccharides have been proposed as healthcare supplements, the mechanism by which they elicit their functions remains to be addressed. Our research is at the interface of immunology and glycobiology, and employs multidisciplinary methodologies of immunology, molecular biology, and chemistry.
Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation
The Journal of Immunology 193 p1560
Publisher’s version: 10.4049/jimmunol.1303278
1999 - 2003 B.Sc. in Chemical engineering, Nagoya University, Japan
2003 - 2005 M.Sc. in Bioscience, The University of Tokyo, Japan
2005 - 2008 Ph.D. in Bioscience, The University of Tokyo, Japan
2008 - 2013 Postdoctoral fellow, The Scripps Research Institute
2013 - Career-track Research Leader, The Institute of Food Research