Prof. Simon Carding
WebsiteGut Health and Food Safety Programme
Current research interests are, defining the link between the mucosal immune system, dendritic cells (DC) and lipid metabolism using a novel experimental model of obesity, the role autophagy plays in intestinal epithelial cell homeostasis, barrier function and mucosal immune responses to commensal and pathogenic microbes, the nature of mucosal immune cell (iIEL)-microbiota interactions in establishing and maintaining a healthy intestinal microbiome while mounting immediate response to food‑borne pathogens, regulation of epithelial tight junctions and the maintenance of intestinal barrier function, interkingdom macromolecule exchange in microbe-host crosstalk and the establishment of mutualism in the GI-tract, development of novel strategies to treat and prevent chronic intestinal inflammation and IBD using SMART bacteria and novel foods, immune tolerance and implant rejection and, immunosenescence and diet.
In 2008 I took up the position of Professor of Mucosal Immunology at UEA-MED and leader of the Gut Biology Research Programme, which eventually became part of the Gut Health and Food Safety (GHFS) Programme. The GHFS programme comprises 13 research groups led by individual group leaders that cover a broad area of gut biology including epithelial cell physiology and epigenetics, mucus and glycobiology, mucosal immunology, commensal microbiology, foodborne bacterial pathogens, and mathematical modelling and bioinformatics.
Genome Announcements vol. 4 no. 6 pe01335-16
Publisher’s version: doi:10.1128/genomeA.01335-16
Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets, Phenotype, and Function Between the Proximal and Distal Colon
Cellular and Molecular Gastroenterology and Hepatology 2 p2239
Publisher’s version: 10.1016/j.jcmgh.2015.08.006
A Novel Tightly Regulated Gene Expression System for the Human Intestinal Symbiont Bacteroides thetaiotaomicron
Frontiers in Microbiology 7 p1080
Publisher’s version: 10.3389/fmicb.2016.01080
A role for the intestinal microbiota and virome in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?
Journal of Clinical Medicine 5 p55
Publisher’s version: 10.3390/jcm5060055
Journal of Immunology 196 p217-31
Publisher’s version: 10.4049/jimmunol.1501064
Elucidating pathways of Toxoplasma gondii invasion in the gastrointestinal tract: involvement of the tight junction protein occludin.
Microbes and Infection 17 p698-709
Publisher’s version: 10.1016/j.micinf.2015.07.001
An event held in Norwich gave the public a chance to hear about biomedical research on the debilitating condition MEmore +
Researchers on the Norwich Research Park have published a review of evidence for a role of the gut microbiota and virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.more +
Can you take the heat of the Chilli M.E. Challenge?more +
Prof. Simon Carding describes our current understanding of the human gut and its relationship with its human host in this IFR public lecturemore +
Scientists from the IFR and the University of East Anglia have discovered how certain gut bacteria can protect themselves and others in the gut from antibiotics.more +
PhD MRC-Clinical Research Centre, Harrow, UK, 1985
Visiting Instructor, New York Univ. Sch. Medicine, New York, USA, 1985-1986
Postdoctoral Associate, Yale Univ. Sch. Med, New Haven, USA, 1986-1989
Howard Hughes Fellow, Yale Univ. Sch. Medicine, New Haven, USA, 1989-1991
Assistant/Associate Professor, Univ. Pennsylvania, Phildelphia, USA, 1991-1999
Professor Molecular Immunology, Leeds Univ., Leeds UK, 1999-2008
Professor Mucosal Immunology, Norwich Medical School, UEA, 2008-
Head, Gut Health and Food Safety Research Programme, Institute of Food Research, 2008