The work of the Molecular Microbiology Group at the Institute of Food Research focuses on the environmental response of bacterial food pathogens, the mechanisms of gene regulation, the role of global gene regulation in bacterial virulence, and gene expression during Salmonella infection.

We are using a variety of post-genomic tools, including DNA microarrays, and have pioneered the use of single-copy transcriptional fusions involving Green Fluorescent Protein to allow the visualisation of gene expression in individual bacterial cells.

Vacancies

No current vacancies in the Molecular Microbiology:Salmonella group. For other vacancies at IFR go to http://www.ifr.ac.uk/vacancies/

New Publications

Clarke TA, Mills PC, Poock SR, Butt JN, Cheesman MR, Cole JA, Hinton JC, Hemmings AM, Kemp G, Söderberg CA, Spiro S, Van Wonderen J, Richardson DJ .Escherichia coli Cytochrome c Nitrite Reductase NrfA. Methods Enzymol. 2008;437:63-77 [ Abstract ] [ PDF ]

Papenfort K, Pfeiffer V, Lucchini S, Sonawane A, Hinton JC, Vogel J. Systematic deletion of Salmonella small RNA genes identifies CyaR, a conserved CRP-dependent riboregulator of OmpX synthesis.Mol Microbiol. 2008 Apr 8 [Epub ahead of print] [ Abstract ] [ PDF ]

Mills PC, Rowley G, Spiro S, Hinton JC, Richardson DJ. A combination of cytochrome c nitrite reductase (NrfA) and flavorubredoxin (NorV) protects Salmonella enterica serovar Typhimurium against killing by NO in anoxic environments.Microbiology. 2008 Apr;154(Pt 4):1218-28 [ Abstract ] [ PDF ]

McFarland KA, Lucchini S, Hinton JC, Dorman CJ. The leucine-responsive regulatory protein, Lrp, activates transcription of the fim operon in Salmonella enterica serovar Typhimurium via the fimZ regulatory gene. J Bacteriol. 2008 Jan;190(2):602-12 [ Abstract ] [ PDF ]

Hautefort I, Thompson A, Eriksson-Ygberg S, Parker ML, Lucchini S, Danino V, Bongaerts RJ, Ahmad N, Rhen M, Hinton JC. During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems. Cell Microbiol. 2008 Apr;10(4):958-84 [ Abstract ] [ PDF] [ Supplementary data S1 ][ Supplementary data S2 ][ Supplementary data S3][ Supplementary data S4] [ Supplementary data S5][ Supplementary data S6 ][ Supplementary data S7] [ Supplementary data S8 ][ Supplementary data S9 ] [ Supplementary data S10] [ Supplementary data S11] [ Supplementary data S12 ][ Supplementary data S13 ] [ Supplementary data S14 ][ Supplementary data S15 ][ Supplementary data S16 ][ Supplementary data S17 ]