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"Enthusiasm always and
necessarily prevails over those who are not enthusiastic."
JG Fichte
(Es siegt immer und notwendig
die Begeisterung ueber den, der nicht begeistert ist.)
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Research Interests
My research
interests are partly built on my general interest in 'the big
questions': Why is it as it is? What is the role of man in the
whole thing? Fritjof Capra's well-known books The Tao of Physics (1975) and The Turning
Point (1982) build some bridges between such questions and detailed
scientific projects. Interestingly, already Capra uses the term Systems
Biology, my main research field. Like Capra, I like to think as
'holistic' as possible and useful. I work on all fields in Systems Biology, i.e. data integration,
statistical analyses and dynamic modelling, collaborating with
groups in our institute (Institute
of Food Research), groups
from the Norwich Research Park
(John Innes Centre, The Sainsbury Laboratory, University of East
Anglia) and beyond. Our research covers
genomics, transcriptomics, proteomics and metabolomics.
CV
Diploma (M.Sc.): Biophysics, Humboldt-University Berlin (1992)
Ph.D.: Theoretical Biophysics (Supervisor: Reinhard Heinrich),
Humboldt-University Berlin (1997)
Postdoc 1: Institute of Physics (Chair: Peter Hänggi), University
of Augsburg (1997-1999)
Postdoc 2: Institute of Freshwater Ecology (IGB), Berlin (1999-2002)
Junior research group leader: Fritz-Lipman Institute of Age Research
(FLI), Jena (2002-2007)
Senior research group leader: Institute of Food Research (IFR), Norwich
(2007-present)
Editorial
Program Committee: BIDM/DEXA 2007, GCB 2008, NetSci
2008, BIOINFORMATICS 2010,2011
Journal Referee: Advances in
Complex Systems, AI Communications, Annalen der Physik, Bioinformatics,
BioSystems, BMC Bioinformatics, BMC Evolutionary Biology, BMC Research
Notes, BMC Systems Biology, Cell Biochemistry and Biophysics,
Complexity, Gene, Genome Biology, IET Systems Biology, Journal of
Mathematical Chemistry, Journal of Molecular Evolution, Journal
of Theoretical Biology, Molecular Microbiology, Molecular Systems
Biology, Physica A, Physical Review E, Physical Review Letters,
PLoS Computational Biology, PLoS One, Proceedings of The Royal Society
B, Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Grant Referee: Biotechnology and Biological
Sciences Research Council (BBSRC, UK), Centre
Européen de Calcul Atomique et Moléculaire (CECAM,
Switzerland), Deutsche
Forschungsgemeinschaft (DFG, Germany), Dutch National Science
Foundation (NOW, Netherlands),
Icelandic Centre for Research
Tools
- DiProGB - a
genome browser considering physical properties of nucleic acids.
- DASS-GUI - a user interface
for data mining (and biclustering).
Selected Publications
- J.
Hollunder, M. Friedel, M. Kuiper, T. Wilhelm. DASS-GUI: a user
interface for identification and analysis of significant patterns in
non-sequential data. Bioinformatics 26 (2010) 987-989.
- T. Wilhelm. The smallest
chemical reaction system with bistability. BMC
Systems Biology 3 (2009) 90. Origin of life.
- M.
Friedel, S. Nikolajewa, J. Sühnel, T. Wilhelm. DiProGB:
the dinucleotide properties genome browser. Bioinformatics 25
(2009) 2603-2604.
- T. Wilhelm.
Analysis of structures causing instabilities. Phys.
Rev. E 76 (2007) 011911.
- R.
Brockmann, A. Beyer, J.J. Heinisch, T. Wilhelm. Post-transcriptional
expression regulation: What determines translation rates? PLoS
Comput. Biol. 3 (2007) 531-539.
- T. Wilhelm, P. Hänggi.
Power-law distributions resulting from finite resources. Physica
A 329 (2003) 499-508.
-> Our world is not just red queen, but also wu wei.
- T. Wilhelm, R. Brüggemann.
Goal functions for the development of natural systems. Ecol.
Model. 132 (2000) 231-246.
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